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KMID : 1145520160020020103
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Journal of Radiopharmaceuticals and Molecular Probes
2016 Volume.2 No. 2 p.103 ~ p.107
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The development of a fully automated homemade system for [11C] acetate synthesis using an open source PLC
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Kang Se-Hun
Hong Sung-Tack
Park Kwang-Seo
Kim Seok-Ki
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Abstract
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Solid phase extraction (SPE) purification method is the efficient and well-known tool for automated [11C]acetate synthesis. A fully automated homemade module adopting the SPE method and ‘pinch’ valves was developed very economically with a universal interface board, a relay card and an open source programmable logic controller. The radiochemical yield of the optimized [11C]acetate synthesis by this system was 58.8 ± 2.1% (n=10, decay-corrected) from 15.5 ± 0.19 GBq of [11C]CO2 as starting activity, and total synthetic time was 15 minutes. HPLC analysis showed its high radiochemical purity as 97.4 ± 1.1% without possible by-products.
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KEYWORD
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[11C]acetate, automated synthesis, homemade module, PET imaging
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